Una unidad asistencial sin vocación investigadora no puede llegar a la excelencia clínica deseada. Por este motivo, la investigación clínica es también nuestra prioridad. El uso de una misma base de datos y la creación de bancos de imágenes y muestras biológicas facilitará la realización de estudios pioneros en el campo cardiovascular y, a la vez, permitirá cuantificar el impacto de esta iniciativa en la salud cardiovascular de la población del entorno.
Los proyectos de investigación que se realizan en la UDETMA están orientados principalmente a:
The presence of the allele T of the SNP rs495392 of the Klotho gene is associated with a decrease in the odds of progression of atheromatosis in CKD patients.
LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes.
The prevalence of subclinical atherosclerosis and the main predictors of progression of this condition in patients undergoing peritoneal dialysis (PD) have been insufficiently investigated.
Advanced glycation end-products (AGEs) are increased and predict mortality in patients with chronic kidney disease (CKD) who are undergoing hemodialysis, irrespective of the presence of type 2 diabetes.
The association of hemoglobin with higher Adventitial Vasa Vasorum could suggest the role of high hemoglobin in the higher incidence of adverse cardiovascular outcomes in Chronic Kidney Disease patients.
The quantification of proteinuria with the protein to creatinine ratio (PCR) is influenced by the excretion of creatinine, which, in turn, varies according to muscle mass and hence, to gender.
The objectives of the ILERVAS project are: (1) to determine the prevalence of subclinical arterial disease and hidden kidney disease; (2) to assess the impact of early diagnosis of both diseases on cardiovascular morbidity and mortality and also on the progression of CKD; (3) to have a platform of data and biological samples.
The aim of this study is to evaluate the prevalence and associated factors of pathological ABI values in CKD patients.
Diabetic patients receiving dialysis therapy are at high risk of foot complications and should receive appropriate and intensive foot care.
The ILERVAS project will reveal the prevalence of subclinical vascular disease and hidden kidney disease, determine whether or not their early diagnosis brings health benefits and will also allow investigation of new risk factors.
Ultrasonographic detection of subclinical atheromatosis is a noninvasive method predicting cardiovascular events. Risk factors predicting atheromatosis progression in CKD are unknown. Predictors of atheromatosis progression were evaluated in patients with CKD.
Soluble TNF–like weak inducer of apoptosis (sTWEAK) is a proinflammatory cytokine belonging to the TNF superfamily. sTWEAK concentrations have been associated with the presence of CKD and cardiovascular disease (CVD).
Endothelial cell activation leading to leukocyte recruitment and adhesion plays an essential role in the initiation and progression of atherosclerosis.
La crisis hipercalcémica es una forma de presentación poco frecuente del hiperparatiroidismo primario. Solo existen pequeñas series de casos reportadas en la literatura. Se caracteriza por hipercalcemia severa, insuficiencia renal y alteración del estado de conciencia.
Warfarin, a widely used anticoagulant, is a vitamin K antagonist impairing the activity of vitamin K-dependent Bone Gla Protein (BGP or Osteocalcin) and Matrix Gla Protein (MGP).
The current nurse-led study shows that subjects with type 2 diabetes mellitus have a high prevalence of subclinical atherosclerosis that is associated with cardiovascular risk factors.
Cardiovascular disease (CVD) is the leading cause of mortality among subjects with type 2 diabetes (T2D), and diabetic retinopathy (DR) has been associated with an increased risk for CVD.
The early identification of the onset of subclinical atheromatosis is essential in reducing the high mortality risk from cardiovascular disease (CVD) worldwide.
Despite the presence of vitamin D receptor (VDR) in endothelial cells, the effect of vitamin D on endothelial function is unknown.
There is growing evidence suggesting that phosphate intake is associated with blood pressure levels. However, data from epidemiological studies show inconsistent results.
The inhibition of the renal renin-angiotensin system by the active form of vitamin D contributes to the cardiovascular health benefits of a normal vitamin D status
Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinase (RTK) signaling. As such, they restrain proliferation of many cell types and have been proposed as tumorsuppressor genes.
Vascular calcification (VC) contributes to high mortality rates in chronic kidney disease (CKD). High serum phosphate and FGF23 levels and impaired phosphaturic response to FGF23 may affect VC.
Left ventricular hypertrophy (LVH), a common complication in chronic kidney disease (CKD), is associated with high cardiovascular mortality.
Chronic kidney disease (CKD) is characterized by a high mortality rate, primarily due to cardiovascular disease.
The kidney handles calcium by filtration and reabsorption. About 60% of the plasma calcium is filterable, and 99% is reabsorbed in the tubule. In the proximal tubule, the reabsorption is passive and paracellular, but in the distal tubule is active and transcellular.
Telomeres are special chromatin sequences located at the end of eukaryotic chromosomes, protecting these regions from recombination and degradation.
Local inflammation is thought to contribute to the progression of diabetic nephropathy. The vitamin D receptor (VDR) activator paricalcitol has an antiproteinuric effect in human diabetic nephropathy at high doses.
Cardiovascular events (CVE) are more prevalent in chronic kidney disease (CKD) than in general population, being the main cause of morbimortality.
The causes of the high cardiovascular mortality observed in chronic kidney disease (CKD) are unknown. Here, we report data on prevalence of subclinical atherosclerosis in the NEFRONA population and...
Background and objectives: Vascular calcification (VC) has a significant effect in cardiovascular diseases on dialysis patients.However, VC is assessed with x-ray-based techniques, which do not inform about calcium localization (intima, media, atherosclerosis-related).
The measurement of carotid intima-media thickness (c-IMT) is an accepted surrogate marker of atherosclerosis.
Atherosclerosis is a progressive inflammatory disease of the arterial wall and the main cause of cardiovascular disease. Despite advances in both primary and secondary prevention...
Primary prevention in cardiovascular diseases is based on risk scoring. However, the use of validated...
Carotid ultrasound measurement of carotid intima-media thickness (C-IMT) and detection of plaques is an useful method to better assess...
Current risk stratification of carotid atherosclerotic lesions is based on the...
To evaluate the agreement between contrast-enhanced ultrasound imaging and histopathology in an animal model of atherosclerosis.
Proliferation of the adventitial vasa vasorum (VV) is inherently linked with early atherosclerotic plaque development and vulnerability.
Physical exercise has multiple beneficial health effects. Yearly, over five million persons walk a pilgrimage in various parts of the World, and this number is increasing.
Cardiovascular risk scoring (Score) does not specifically address chronic kidney disease (CKD) patients.
The presence of the receptor has been detected in the principal organs responsible for calcium homeostasis (kidney and bone), pointing to a possible role in mineral metabolism.
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients...
Histological data associate proliferation of adventitial vasa vasorum and intraplaque neovascularization with...
The origins of contrast enhanced ultrasound imag-ing (CEUS) date to the earliest observations of Claude Joyner and publications of Gramiak and Shah in 1968.1 Interest in the development of ultrasound contrast agents and clinical applications continues today, nearly 40 years later the first reports.
The ankle brachial index (ABI) is a known measure of lower-limb peripheral artery disease (PAD), as well as a marker for other cardiovascular disease events.
Histological data associate proliferation of adventitial vasa vasorum and intraplaque neovascularization with vulnerable...
Vitamin D has proven to be much more than a simple ‘calcium hormone’. The fact that the vitamin D receptor has been found in cells not related to mineral metabolism supports that statement.
Background: Vitamin D is a steroid hormone known for its role in regulating levels of calcium and phosphorus. Vitamin D has important autocrinelparacrine roles and it is involved in vascular biology.
Hypoxia is a strong stimulus for the induction of angiogenesis. In an elegant series of experiments including in vivo labeling of hypoxic tissues, Sluimer et al have demonstrated that hypoxia in advanced atherosclerotic plaques colocalized with the expression of...
Vascular calcification commonly associated with several pathologies and it has been suggested to be similar to bone mineralization.
Should doctors screen asymptomatic individuals for subclinical disease? That's the question posed and debated in the July 6, 2010 issue of the Journal of the American College of Cardiology, with one expert arguing that noninvasive screening tests...
Atherosclerotic vascular diseases are a major cause of morbidity and mortality for end-stage renal disease patients.
We evaluated the efficacy of statin therapy in primary prevention among individuals with moderate chronic kidney disease (CKD).
Convincing patients to substantially change their lifestyle and, thus, reduce their risk of cardiovascular disease is often challenging. Although they understand the cardiovascular benefits of life-style change, they just can’t bring themselves to give up some of the creature comforts they have become...
By quantifying microbubble retention within the carotid plaque, LP contrast-enhanced US depicts clear differences between groups of subjects with plaque ipsilateral to symptoms and asymptomatic plaques.
Although cardiovascular disease (CVD) is the leading cause of death for women in Europe, and more women die from CVD than from all cancers combined, women - and many of their physicians - remain largely unaware of their risk of developing CVD.
We evaluated whether carotid intima-media thickness (CIMT) and the presence or absence of plaque improved coronary heart disease (CHD) risk prediction when added to traditional risk factors (TRF).
To evaluate the agreement between contrast-enhanced ultrasound imaging and histopathology in an animal model of atherosclerosis
Elevated parathyroid hormone (PTH) levels have been associated with increased cardiovascular risk in the general population.
A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the Society for Vascular Medicine
Carotid ultrasound provides quantitative measurements of carotid intima–media thickness (CIMT) that can be used to assess cardiovascular disease (CVD) risk in individuals and monitor ongoing disease progression and regression in clinical trials.
Cardiovascular disease and other complications of atherosclerosis are the most common cause of death in patients with chronic renal failure in maintenance hemodialysis (MHD). Carotid ultrasonography is a simple non-invasive tool to investigate the vascular system, by means of intima media thickness (IMT) measurement and carotid wall calcifications.
Carotid intima media thickness (cIMT) is an intermediate phenotype of early atherosclerosis that independently predicts vascular events.